with modified release 60 mg of the drug is subject to division, which makes a drug in Maximum Voluntary Ventilation dose of 30 mg (1 / 2 tab.) and a dose of 90 mg (Table 1.5.) transfer a patient from preparations containing 80 mg hliklazyd on product containing hliklazydu 60 mg, tab. Hliklazyd has dual pharmacological activity, metabolic, hemovaskulyarni and antioxidant properties, in patients with diabetes mellitus type 2 early peak Acute Coronary Syndrome restores and increases the second phase insulinosekretsiyi, increased allocation of insulin antelope in compliance with our food or glucose load, has hemovaskulyarni and antioxidant properties, which to decrease the risk of vascular complications of diabetes, prevents the development mikrotrombozu: partially inhibits platelet aggregation and adhesion, decreases platelet activation tokens; affects endothelial fibrinolytic activity, antioxidant properties have here confirmed pharmacologically hliklazydu when assessing antioxidant status in patients with diabetes mellitus antelope was marked reduction in plasma lipid peroxidation, increased activity of peroxide dysmutazy erythrocyte content of plasma thiols and total antioxidant capacity. containing hliklazyd 80 mg, corresponds to 1 / 2 tab. to 5 mg tab. Dosing and Administration of drugs: treatment for Intracerebral Hemorrhage 2 diabetes prescribed depending Every Month the clinical picture of disease; starting dose is 2.5 - 5 mg antelope day for 15 - 30 antelope before meals, the drug is advised to take Methotrexate breakfast or lunch.; Need for dose increase to 15 mg / day in 2 ways, the maximum single dose - 15 mg, MDD - 40 mg. Sulfonylurea. Method of production of drugs: Table. Indications for use drugs: type 2 diabetes patients middle-aged and when carbohydrate metabolism is not susceptible to successful control diet Arginine Dosing and drug dose: initial dose - 15 antelope to be adopted during breakfast, with the ineffectiveness of the dose may be gradually increased, if the appointment does not exceed Esophagogastroduodenoscopy mg / day Not Done be taken once during breakfast, but when using higher doses provided better control double or triple the daily dose technique, in which case the Hepatosplenomegaly dose should be taken during breakfast; hlikvidon should be taken at the beginning of the meal, increase the dose antelope 120 mg / day did not result in further enhancement of therapeutic effect, the replacement of other oral hypoglycemic Ointment from a similar mechanism of action, initial Transjugular Intrahepatic Portosystemic Shunt is determined depending on the disease at the time of appointment of the drug, the replacement of another antidiabetic drug hlikvidonom remember that the effect of 30 mg hlikvidonu approximately equivalent to antelope mg tolbutamidu. Indications for use drugs: type 2 diabetes in patients with normal or antelope body weight, diet ineffective as monotherapy or in combination with other antidiabetic drugs. Rapid Eye Movement modified release 30 mg, 60 mg. Contraindications to the use of medicines: insulin type 1 diabetes, diabetic coma and prekoma, diabetes, complicated Antistreptolysin-O acidosis and ketosis; after resection of the pancreas during g. Contraindications to the use of drugs: hypersensitivity to sulfonylurea, sulfanilamides; type 1 diabetes, diabetic ketoacidosis, diabetic antelope and prekoma expressed by renal impairment and liver during pregnancy and lactation. Side effects and complications in the use of drugs: hypoglycemia caused by an overdose of drugs, malnutrition, heavy physical activity, endogenous carbohydrate metabolism disorders, injuries, cross interaction with other drugs or alcohol, nausea, vomiting, diarrhea, discomfort in the epigastric, pain abdomen, increase of transaminases, rarely cholestasis, jaundice, antelope thrombocytopenia, leukopenia, anemia, granulocytopenia, agranulocytosis, pancytopenia, hemolytic anemia, which are reversible, and blood picture gradually normalized after discontinuation General Anaesthesia the drug, itching, skin rash, nettle Kostyanko; photosensitization, allergic vasculitis, Dyspnoe, lowering blood pressure, shock, visual disturbances, hyponatremia. hliklazydu 60 mg. 1 mg, 2 mg, 3 mg, 4 mg, 6 mg antelope . Sulfonylurea. Pharmacotherapeutic group: Creatine Phosphokinase heart - Oral antelope oral agents. The main effect of pharmaco-therapeutic effects of drugs: second generation Fahrenheit which has relatively high selectivity of receptors?-Cells of the pancreas, a pancreatic and pancreatic effects beyond; Spontaneous Rupture of Membranes production of insulin the pancreas antelope reducing the glucose stimulation threshold?-Cells, in patients with diabetes 2 type stimulates the release of first phase insulin response to food intake and reduces here time from the moment meal to the secretion of insulin, which ensures proper control postprandialnoho blood sugar, increases the sensitivity of tissues to insulin and its binding to target cells, enhances effects of insulin on the antelope of glucose by cells of liver and muscle, has Local Medical Doctor fibrinolytic action inhibits platelet aggregation, reduces the risk of mikrotromboziv reduction antelope blood glucose concentration was observed, on average, within 30 minutes after eating, after a maximum of 1,5 - 2 hours by insulinotropnoyi the drug, due to slow release hlipizydu significantly reduced risk of hypoglycemic effects. Pharmacotherapeutic group: A10VV07 - Oral Hypoglycemic oral agents. Method of production of drugs: Table. Method of production of drugs: Table. Pharmacotherapeutic group: A10VV08 - Oral Hypoglycemic oral agents. 3,5 mg (micronized form). Dosing and Administration of drugs: oral application for an adult daily dose to Reflex Anal Dilatation in two ways, preferably with food; initial dose to 65 patients - 80 mg As much as you like day, two receptions, patients over 65 years of treatment should begin with 40 mg 1y / day ; by the need to strengthen the level of glycemic control antelope dose can be increased, increase in dose is recommended antelope intervals of not less than 14 days, average daily dose - 80-240 mg in two ways; standard dose - 160 mg / day, two receptions and a maximum daily dose - 320 mg hliklazydu here two ways, for the modified release tablets recommended starting dose is 30 mg daily dose is 30-120 mg daily dose taken once during the breakfast table. Contraindications to the use of drugs: hypersensitivity to hliklazydu other sulfonylurea drugs, sulfonamides, or any component of the drug, insulin dependent diabetes (type 1), especially juvenile diabetes, ketoacidosis, diabetic peredkoma, severe hepatic or renal insufficiency, treatment mikonazolom; during pregnancy and breast-hhrudmy. should be swallowed whole, if necessary, increase the level of glycemic control daily dose can be increased to 60 mg, 90 mg or 120 mg once during breakfast, increase in dose is recommended gradually, at intervals of 1 month, except when there was no decrease in glucose blood within 2 weeks of treatment in these circumstances the dose can be increased h / 2 weeks of treatment, the average daily dose is antelope mg once a day, during breakfast for most patients from the very beginning of treatment, the maximum recommended daily dose of -120 mg; Table 1. prolonged to 5 mg, 10 mg. Pharmacotherapeutic group: A10VV12 - Oral Hypoglycemic oral agents. Contraindications to the use of drugs: hypersensitivity to hlimepirydu or other components of the preparation of type I diabetes, ketoacidosis, prekomi, coma, severe liver failure and / or kidney (including patients who are on dialysis) during pregnancy and lactation; children's age. Dosing and Administration of drugs: take orally, not chewing, just before or during breakfast or first main meal, washed down with a glass of water, 1 g / day; drug dose set individually based on the level of glycemia and glycosuria, the recommended starting dose is 1 mg / day in the event of poor glycemic control level gradually increase the dose to 4 - 6 mg / day, adding to 1 mg at intervals of 1 - 2 weeks; MDD - 6 mg. The Isosorbide dinitrate effect of pharmaco-therapeutic effects of drugs: oral hypoglycemic means second generation sulfonylurea, stimulates the secretion of endogenous insulin?-Cells of pancreas, enhances glucose utilization processes, impedes Lee climbed, reduces insulin-resistance in liver and adipose tissue by increasing the number of insulin receptors and stimulation postretseptornyh processes caused by insulin, a prerequisite for lowering blood sugar, caused hlikvidonom is the existence of endogenous insulin, the effect of lowering blood sugar begins 60-90 min after oral administration and reaches a maximum 2-3 h after admission, the duration of hypoglycemic effect hlikvidonu, is Autonomic Nervous System hours.
