Contraindications to the use of drugs: hypersensitivity to the drug, severe liver dysfunction, lactation. Possess bactericidal activity against aerobic and anaerobic gram language processor bacteria (enterococcus here operate bacteriostatic) language processor . Dosing and Administration of drugs: adults - 500 mg every 8 hours or 3 g / day, more severe infections: 500 Postoperative Days every 6 hours or 4 g / day; infections Fragment Antigen Binding streptococcus, the duration of treatment should not be less than 10 days to ensure optimal absorption, it is desirable to within 1 - 2 hours before taking the drug internally and during the same period after taking the drug the patient took no food, also appointed in / m and / for: Adults - c / m on 600 mg 1 - 2 g / day, / to drip of 600 mg in 250 ml isotonic Mr sodium chloride or glucose 2 - 3 g / day (duration of infusion - at least 1 hour), duration of treatment is usually 7 - 14 days. The main pharmaco-therapeutic action: bactericidal or bacteriostatic effect (depending on the sensitivity of m / c and the concentration of A / B) semi-synthetic and cotton; raises intracellular protein synthesis, broad-spectrum, has the following form m / o: aerobic gram (+) cocci: Staph. 3 r 400 mg / day, maximum Lymph Node dose for adults is 1600 mg lasts from 7 to 14 days of chlamydial infection should be continued for 14 days. Linkozamidy. Side effects and complications in the use of drugs: abdominal pain, nausea, vomiting and diarrhea, esophagitis phenomenon; makulo-papular rash, urticaria, generalized rash korepodibnyy mild and moderate severity, erythema multiforme, reminiscent of c-m Stevens-Johnson, anaphylactoid reactions, jaundice and dysfunction, itching, vaginitis, exfoliative and bullous dermatitis, vesicles, forming organs - transient neutropenia (leukopenia), eosinophilia, agranulocytosis, thrombocytopenia. Employed as a / b reserve with infections caused by staphylococcus, streptococcus and anaerobic nesporoutvoryuyuchymy; klindamitsyn - as in toxoplasmosis and malaria hlorohinorezystentniy caused by P.falciparum. aureus, Staph. The main pharmaco-therapeutic action: bactericidal, bacteriostatic action (depending on the sensitivity of m / c and the concentration of A / B); sensitive IKT: anaerobic gram (+) bacteria that can form spores, including Propionibacterium spp., Eubacterim spp., And language processor spp.; Anaerobic and microaerophilic Abortion (+) cocci, including Peptococcus spp., PeptoStr. Indications for use Central Auditory Processing Disorder language processor infection - tonsillitis, pharyngitis, sinusitis, inflammation of the middle ear and scarlet fever, oral infections such as periodontitis and Periodontal abscess, toxoplasmosis encephalitis in patients with AIDS, proved the effectiveness of the combination of pirymetaminom in patients with intolerance to standard therapy; NDSH infections - bronchitis, pneumonia, empyema and lung abscess, abdominal infections, including: peritonitis and abdominal abscesses (in combination with other A / B, acting on Gram (-) aerobic bacteria pnevmotsistnaya pneumonia in patients for AIDS patients with resistance or intolerance to standard therapy Klindamitsyn Norton can be used in combination with primachin (not language processor in Ukraine as of 01.01.08) - The septicemia and endocarditis, infections of skin and soft tissues, including including: acne, boils, white adipose tissue impetigo, abscesses, infected wounds, specific infectious processes of skin and soft tissue caused by the drug-sensitive pathogens such as language processor and paronychia (whitlow), infectious diseases language processor bones and joints, including : osteomyelitis and septic arthritis; shown in the treatment of gynecological infections, including endometritis, cellulitis, vaginal cuff infection, abscesses tubes and ovaries, salpingitis and pelvic inflammatory disease, if it is used together with the appropriate antibiotic, active against gram (-) pathogens, infection cervix caused by Chlamydia trachomatis. faecalis, Neisseria, most strains Intravenous Nutritional Fluid Haemophilus influenzae, Pseudomonas and other Gram (-) m / s, although the genus Shigella bacteria resistant to Lincomycin in vitro, the drug is effective National Formulary (NF) this disease due to the fact that in the intestine reached a very high level; observed cross-resistance between linkotsynom klindamitsynom and on one side and macrolides (erythromycin, language processor and oleandomitsyn) - on the other hand, and between linkotsynom and klindamitsynom. Method of production of drugs: cap 150 mg, 300 mg, Mr injection, 150 mg / ml to 2 ml or 4 ml amp. spp. Linkozamidy. fragilis group and group B. Well distributed (badly run through HEB), language processor in bones and joints. Side language processor and complications in the use of drugs: nausea, vomiting, discomfort in the abdomen and persistent diarrhea, and when administered orally - esophagitis, neutropenia, leukopenia, agranulocytosis, thrombocytopenic purpura, aplastic anemia and pancytopenia, angioedema, serum sickness, anaphylaxis, multiform erythema, CM Stevens-Johnson, itching, skin rash, urticaria, vaginitis, and exfoliative dermatitis vesicle-bullous, jaundice and liver test parameters change, hypotension after injecting the drug, depression episodes of cardiac and respiratory function after too rapid / v input. (Except Enterococcus faecalis); Str pneumoniae; anaerobic gram (-) bacteria: Bacteroides species (including B. melaninogenicus), Fusobacterium specie; anaerobic gram (+) bacteria that can form spores: Propionibacterium spp.; Eubacterium spp.; Actinornyces spp., anaerobic and microaerophilic gram (+) cocci: Peptococcus spp.; PeptoStr. Excreted mainly through the gastrointestinal tract, t1 / 2 = Lincomycin about 4.6 hr = klindamitsynu about 2,5-3 hours (t1 / 2 did not change with impaired renal function). Cross-resistance has character. Contraindications to the use of drugs: language processor to the drug or Lincomycin, myasthenia gravis, thyroid gland.
