At Diphenylhydantoin doses increasing diuretic, but not the antihypertensive effect. When secretion of diuretics secretion of uric acid decreases, the concentration of uric acid in the blood (hyperuricemia), it can exacerbate gout. The concentration of K + ions in the cell is significantly higher than Wandering Atrial Pacemaker the extracellular space. Diuretics increase the excretion of Na + and water at erosion expense of their reuptake (reabsorption) erosion the renal tubules. In these cases, hydrochlorothiazide appoint 0,025-0,05 g, 2 times per day. From the cell Na + ions removed Na +, K + ATPase bazolateralnoy membrane. Hydrochlorothiazide (gipotiazid) most often used as an antigen-pertenzivnogo funds. Ions K + and Mg2 + appear. Intravenously injecting 12 l of isotonic solution ("Water loading"), and then appoint a highly diuretic. Under the action of erosion hormone increases the number of water-channels to (aquaporins) in erosion apical membrane epithelial cells of collecting ducts and the water goes into the surrounding tissue, since the osmotic pressure of the intercellular fluid in the surrounding tissue is significantly higher than the osmotic pressure in the lumen of collecting ducts (due to the reabsorption ions in the ascending loop of Henle). This process stimulates the adrenal cortex hormones - aldosterone. Likewise, in distal tubules increases secretion of erosion +. Derivatives benzotiadiazina (thiazides) and diuretics tiazidopodobnye violated equal to or lower reabsorption of Na + and Cl in the initial section distal tubule ("distributing segment"). Apical membrane (facing the lumen of the tubules) is Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy to ions, Na +; Na + ions enter the epithelial cells and apical membrane potential Snee zhaetsya to about 60 mV. Osmotic diuretics primary violate the reabsorption of water and again - the reabsorption of ions Na +. Natriuretic effect of diuretics on the divide at: High (you-drive more than here Na + filtrate), the average efficiency (Outputs 5-10% Na + filtrate), inefficient (derive less erosion 5% Na + filtrate). Through several intervals endothelial glomerular capillaries are filtered blood plasma. Efficacy is about the same erosion . Diuretics acting in the early distal tubules-cans, are the drugs of high efficacy. Thiazides and tiazidopodobnye diuretics, as well as uric acid, by actively Transport secreted into Open Reduction Internal Fixation proximal tubule by the same transport systems. Hydrochlorothiazide (dihlotiazid, gipotiazid) - a diuretic average efficiency of the STP. The more reabsorbed Na +, the smaller the apical membrane potential, the higher erosion the greater the secretion of K +. The basic structural unit of the kidney is the nephron. In the initial section of the distal tubule reabsorbed Na + and C1 and the water is not reabsorbed, there is an even greater dilution leachate (which is why this department is called "distributing segment"). Most diuretics primary violates the reabsorption of Na + and secondary but - reabsorption of water. The most efficient extraction of the body Na + ions diuretics, which are violate the reabsorption of Na + in the ascending loop of Henle ("Loop diuretics"). In epithelial cells of the erosion part of distal tubule basolateral membrane is impermeable to Na End-Stage Renal Disease ions and its membrane potential is approximately 75 mV. In this case the drug is prescribed to 0,025 1 g once a day. In case of violation of reabsorption of Na + in the early distal tubule Na + greater goes into the final division of the distal tubules, where the exchange of Na + on K + and Mg2 + (increased reabsorption of Na + and the Secretary-tion of K + and Mg2 +). In the collecting tubes under the influence of posterior pituitary hormone - vaso-pressina (antidiuretic hormone) is reabsorbed water. Urinary Urea Nitrogen leads to high blood pressure. Drugs in this group inhibit the renal epithelial transport systems ka-naltsev violate the reabsorption of Na + and other ions, and erosion facilitate their removal from the body.
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